[Effect of biologically active compounds of divalent platinum on the properties of the liquid crystal 'microphase' of DNA]

Autor:	N M, Akimenko, V, Kleinwächter, Iu M, Evdokimov
Rok vydání:	1983
Předmět:	Male Solutions Structure-Activity Relationship Models Chemical Circular Dichroism Fishes Animals Drug Interactions DNA Crystallization Platinum Polyethylene Glycols
Zdroj:	Antibiotiki. 28(7)
ISSN:	0003-5637
Popis:	The optical properties of the "microphases" modeling the state of the DNA molecule in the cell and formed of both the low molecular DNA and the DNA complexes with cis- and trans-isomers of dichlorodiamine platininum (II) were studied. It was shown that the intensive band characteristic of the circular dichroism spectrum of the initial DNA "microphase" was decreasing with binding of DNA to cis-Pt (II) or trans-Pt (II). The effect of cis-Pt (II) on the "microphase" optical properties was more significant than that of trans-Pt (II). The effect correlated with the biological activity of the cis- and trans-compounds of platinum. Possible causes of the decrease in the optical activity of the DNA "microphase" are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4af9a46b06dbbe8b914ecdd2e1612b47 https://pubmed.ncbi.nlm.nih.gov/6625549 Zobrazit plný text záznamu