[The effect of anti-asthmatic preparations on the proliferation of human peripheral mononuclear cells]

Autor: D B, Uteshev, P S, Prokof'ev, V L, Kovaleva, B S, Uteshev, G I, Storozhanov
Rok vydání: 1999
Předmět:
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia. 62(2)
ISSN: 0869-2092
Popis: The authors studied the effect of some antiasthmatic drugs (theophylline, budesonide, sodium cromalyne) and beta-carotene in vitro on spontaneous and PHA-induced proliferation of human peripheral blood mononuclears (PBMN). It was found that the drugs had no effect on spontaneous cell proliferation. But budesonide caused a 4-fold and beta-carotene a 6-fold decrease of the index of PHA-stimulated PBMN proliferation. It is concluded that beta-carotene may be used in clinical practice as an anti-inflammatory agent for bronchial asthma treatment.
Databáze: OpenAIRE