| Autor: |
Heba A, Hassan, Iriny M, Ayoub, Tamer I M, Ragab, Sherif M, Afifi, Abd El-Nasser G, El-Gendy, Abdel Razik H, Farrag, Ahmed M, Abd-ELGawad, Mohamed, Farag, Abdelsamed, Elshamy, Naglaa M, Ammara |
| Rok vydání: |
2022 |
| Zdroj: |
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. |
| ISSN: |
1366-5804 |
| Popis: |
Gastric ulcer (GU) a widely distributed ailment is associated with many causes, including alcohol consumption.Chemical profiling ofUPLC-MS profiling of SSEE identified 75 components belonging to various classes. Compared with control, EtOH-treated rats showed decreased of tissue GSH, TAC and PGE2 by 62.32%, 51.85% and 47.03% respectively. SSEE and SSEE-N-Ag administration mitigated biochemical and histopathological alterations. Serum metabolomics analysis revealed for changes in several low molecular weight metabolites with ulcer development. These metabolites levels were restored to normal post-administration of SSEE-N-Ag. SSEE-N-Ag as mediated via modulating numerous metabolic pathways such as lipids, pyrimidine, energy metabolism and phosphatidylinositol signaling. This study provides novel insight for metabolic mechanisms underlying gastric ulcer relieving effect.Present results revealed potential antiulcer effect of SSEE and SSEE-N-Ag by decreasing ulcer-associated syndromes, supporting their anti-ulcerogenic action. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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