| Autor: |
A J, Fenton, B E, Kemp, R G, Hammonds, K, Mitchelhill, J M, Moseley, T J, Martin, G C, Nicholson |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Endocrinology. 129(6) |
| ISSN: |
0013-7227 |
| Popis: |
We have recently shown that a carboxyl-terminal sequence of parathyroid hormone-related protein, PTHrP[107-139], is a potent direct inhibitor of osteoclastic bone resorption. We now report that this bone resorption inhibitory activity, which we have called osteostatin, is entirely contained within the highly conserved pentapeptide PTHrP[107-111]. Our results indicate that processing at residue 106 and a free amino terminus is required for full activity of the peptide. The retroinverted peptide is considerably less potent than the parent peptide. The retention of full biological activity in such a short fragment was unexpected. This data provides the basis for the development of further analogs with potential therapeutic use in disorders associated with increased osteoclastic bone resorption. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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