| Autor: |
S, Landaas, J E, Pettersen |
| Rok vydání: |
1975 |
| Předmět: |
|
| Zdroj: |
Scandinavian journal of clinical and laboratory investigation. 35(3) |
| ISSN: |
0036-5513 |
| Popis: |
Urine and blood samples from patients with different clinical disorders were examined for 2-hydroxybutyric acid (2-HB) by gas chromatography and mass spectrometry. All patients with combined lactic acidosis and ketoacidosis excreted 2-HB in the urine, in amounts up to 2.3 mmol/mmol creatinine. In blood from these patients, 2-HB was present only in trace amounts. Hard physical exercise resulted in lactic acidosis and accumulation of 2-HB. The lactate to pyruvate ratio in blood and urine was markedly increased in the patients excreting 2-HB but was normal in two patients with lactic acidosis who did not excrete 2-HB. It is concluded that an increased NADH2/NAD ratio is the most important factor for the production of 2-HB. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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