| Autor: |
X M, Duan, G Y, Zhang, E S, Wu |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. 25(4) |
| ISSN: |
1000-5625 |
| Popis: |
To evaluate the relationship between FHIT gene and gastrointestinal cancers.Matched normal and cancerous tissues from 26 patients with primary gastric carcinoma and 30 patients with colorectal carcinoma were analysed by nested polymerase chain reaction(RT-PCR) and direct sequencing of the products.Seven of 26(26.9%) gastric cancer tissues and eight of 30(26.7%) colorectal cancer tissues expressed aberrant FHIT transcripts, but no aberrant FHIT transcript was observed in all the matched normal tissues. Sequence analysis of the aberrant transcripts of 2 gastric cancer tissues(G8T, G25T) and 2 colorectal cancer tissues(C5T, C26T) confirmed the absence of 1 to 3 exons of FHIT gene.The expression of aberrant FHIT transcripts is common and tumor-specific in gastrointestinal cancers and abnormalities of FHIT gene may be associated with gastrointestinal tumorigenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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