Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in Turkey
| Autor: | Yilmaz, Cakaloğlu, Filiz, Akyüz, Mürvet, Bozaci, Duygu, Ibrişim, Binnur, Pinarbaşi, Kadir, Demir, Sabahattin, Kaymakoğlu, Fatih, Beşişik, Selim, Badur, Atilla, Okten |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Torque teno virus Genotype Hepatitis D Chronic Turkey Blood Donors Comorbidity gamma-Glutamyltransferase Hepatitis C Chronic Alkaline Phosphatase DNA Virus Infections Hepatitis B Chronic Treatment Outcome DNA Viral Prevalence Humans Female Aspartate Aminotransferases Retrospective Studies |
| Zdroj: | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 19(2) |
| ISSN: | 2148-5607 |
| Popis: | SEN viruses are transmitted parenterally and can cause post-transfusion hepatitis. The prevalence and clinical significance of SEN viruses have been investigated in patients with chronic hepatitis C and B but not in D. We aimed to determine the prevalence and clinical significance of SEN viruses- H in patients with chronic hepatitis C, B and delta in Turkey.SEN viruses-H was analyzed in 85 patients with chronic viral hepatitis (30 HCV, 30 HBV and 25 HDV) and 43 non-professional blood donors. HBV DNA, HCV RNA and HDV RNA were positive in patients with hepatitis B, C and D, respectively. SEN viruses-H DNA was detected by semi-nested polymerase chain reaction method (L2AS, C5S primer in first step, L2AS, D11 in second step) after extraction of DNA from sera (NucleoSpin blood; Macherey-Nagel GmbHCo KG, Germany).SEN viruses-H DNA was found to be positive in 7/30 (23.3%), 10/30 (33.3%), 6/25 (24%), and 7/43 (16.2%) of patients with chronic C, B, and D hepatitis and healthy blood donors, respectively. There was no significant difference in clinical features and treatment response between SEN viruses- H-positive and -negative patients with chronic viral hepatitis.SEN viruses is more frequent in chronic hepatitis patients than in healthy blood donors. These results indicate that SEN viruses has no effect on the clinical course and treatment response of chronic viral hepatitis. |
| Databáze: | OpenAIRE |
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