| Autor: |
He-qing, Li, Yu-min, Zhu, Jiang-bo, Chen, Guo-lin, Tan |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 32(3) |
| ISSN: |
1672-7347 |
| Popis: |
To evaluate the effect of genomic instability on prognostics in nasopharyngeal carcinoma.Genomic instability was assessed by inter-simple sequence repeats polymerase chain reaction (inter-SSR PCR) in 38 patients with nasopharyngeal carcinoma. Characterization and verification of band alterations shared in different tumors were carried out by sequencing and nest PCR.Thirty-one (81.6%) of the 38 patients showed genomic altercations, and genomic instability index ranged 0 to 16.2 percent. A gain-based genomic damage shared in 6 tumors was identified on chromosome 6q27. Genomic alteration was significantly more in patients less than 5-year survival than those with more than 5-year survival (P0.05).Genomic instability can be an early event marker in carcinogenesis of nasopharyngeal carcinoma. Aggravation of genomic alterations is a poor prognosis for cancer recovery. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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