[Features of primary structure of genes and proteins from passaged variations of measles virus]

Autor:	S G, Markushin, L Iu, Taros, P, Rota, V, Bellini, I B, Koptiaeva
Rok vydání:	2001
Předmět:	Base Sequence Genes Viral Virulence Viral Proteins Amino Acid Substitution Measles virus Culture Techniques Chlorocebus aethiops Mutation Animals RNA Viral Amino Acid Sequence Serial Passage Vero Cells
Zdroj:	Voprosy virusologii. 46(5)
ISSN:	0507-4088
Popis:	Primary structure and proteins of measles virus variants passaged in tissue culture were studied. The findings suggest that genetic determinants responsible for measles virus attenuation are not linked with the genes coding for envelope proteins and nucleoprotein of this virus. However the detected nucleotide substitutions can be considered as the main prerequisites for the appearance of mutations in other regions of viral genome, leading to decrease of virulence for humans.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4a5fd048210af0a7d757fdff686f942f https://pubmed.ncbi.nlm.nih.gov/11715703 Zobrazit plný text záznamu