Loss of growth arrest DNA damage genes expression in oral melanomas
| Autor: | M, Korabiowska, H, Betke, U, Brinck, U, Grohmann, J F, Hönig, M, Droese |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Aged 80 and over Cell Nucleus Male Intracellular Signaling Peptides and Proteins Proteins Cell Cycle Proteins Middle Aged Antigens Differentiation DNA-Binding Proteins Gene Expression Regulation Neoplastic Protein Phosphatase 1 Biomarkers Tumor CCAAT-Enhancer-Binding Proteins Humans Female Mouth Neoplasms Melanoma Transcription Factor CHOP Aged DNA Damage Transcription Factors |
| Zdroj: | In vivo (Athens, Greece). 13(6) |
| ISSN: | 0258-851X |
| Popis: | 29 oral melanomas were stained immunohistochemically for the GADD34, GADD45 and GADD153. GADD34 was found in 5/29 melanomas and its expression did not exceed 21%, averaging 4.1% of melanoma cells. GADD45 was observed in 8/29 oral melanomas and cell positivity averaged 2.8%. GADD153 was found in 2/29 melanomas and the percentage of positive cells ranged between 0 and 31%, averaging 1.2%. Not one significant correlation between GADD genes in oral melanomas was found. Loss of GADD gene expression and lack of correlation between them show advanced disturbances in their cooperation, leading to a high genetic instability of oral melanoma cells. |
| Databáze: | OpenAIRE |
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