A Model of [Formula: see text] Dynamics in an Accurate Reconstruction of Parotid Acinar Cells
| Autor: | Nathan, Pages, Elías, Vera-Sigüenza, John, Rugis, Vivien, Kirk, David I, Yule, James, Sneyd |
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| Rok vydání: | 2018 |
| Předmět: |
Cell Membrane
Finite Element Analysis Cell Polarity Acinar Cells Mathematical Concepts Models Biological Article Sarcoplasmic Reticulum Calcium-Transporting ATPases Diffusion Imaging Three-Dimensional stomatognathic system Hydrodynamics Animals Humans Inositol 1 4 5-Trisphosphate Receptors Parotid Gland Computer Simulation Calcium Signaling Saliva |
| Zdroj: | Bull Math Biol |
| ISSN: | 1522-9602 |
| Popis: | We have constructed a spatiotemporal model of [Formula: see text] dynamics in parotid acinar cells, based on new data about the distribution of inositol trisphophate receptors (IPR). The model is solved numerically on a mesh reconstructed from images of a cluster of parotid acinar cells. In contrast to our earlier model (Sneyd et al. in J Theor Biol 419:383-393. https://doi.org/10.1016/j.jtbi.2016.04.030 , 2017b), which cannot generate realistic [Formula: see text] oscillations with the new data on IPR distribution, our new model reproduces the [Formula: see text] dynamics observed in parotid acinar cells. This model is then coupled with a fluid secretion model described in detail in a companion paper: A mathematical model of fluid transport in an accurate reconstruction of a parotid acinar cell (Vera-Sigüenza et al. in Bull Math Biol. https://doi.org/10.1007/s11538-018-0534-z , 2018b). Based on the new measurements of IPR distribution, we show that Class I models (where [Formula: see text] oscillations can occur at constant [[Formula: see text]]) can produce [Formula: see text] oscillations in parotid acinar cells, whereas Class II models (where [[Formula: see text]] needs to oscillate in order to produce [Formula: see text] oscillations) are unlikely to do so. In addition, we demonstrate that coupling fluid flow secretion with the [Formula: see text] signalling model changes the dynamics of the [Formula: see text] oscillations significantly, which indicates that [Formula: see text] dynamics and fluid flow cannot be accurately modelled independently. Further, we determine that an active propagation mechanism based on calcium-induced calcium release channels is needed to propagate the [Formula: see text] wave from the apical region to the basal region of the acinar cell. |
| Databáze: | OpenAIRE |
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