Histopathological and aquaporin7 mRNA expression analyzes in the skeletal and cardiac muscles of obese db/db mice

Autor:	WAKAYAMA, Yoshihiro, HIRAKO, Satoshi, OHTAKI, Hirokazu, ARATA, Satoru, JIMI, Takahiro, HONDA, Kazuho
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	cardiac muscle Myocardium Muscle Fibers Skeletal quantitative polymerase chain reaction Mice Inbred Strains db/db mouse Note skeletal Rodent Diseases Mice aquaporin 7 mRNA Internal Medicine Animals Obesity RNA Messenger
Zdroj:	The Journal of Veterinary Medical Science
ISSN:	1347-7439 0916-7250
Popis:	The aim of this study is to examine 1) muscle fiber type composition, 2) myofiber diameter, and 3) aquaporin (AQP) 7 and AQP 9 mRNA expressions by quantitative PCR in muscles of obese db/db mice. The myofiber type composition of skeletal muscle was not statistically significantly different between db/db mice and control mice; while the average myofiber diameter ratio showed a decrease in db/db mice. The expression of AQP7 but not AQP9 mRNA in the skeletal and cardiac muscles was significantly upregulated in db/db mice. Thus this study revealed quantitatively that type 2 myofiber atrophy was shown in the skeletal muscles of db/db mice. AQP7 mRNA expression was upregulated in the skeletal and cardiac muscles of db/db mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4a332acb16318c5e1c4c27933653e24b http://europepmc.org/articles/PMC8349804 Zobrazit plný text záznamu