| Autor: |
Jinqiu, Liu, Fanhua, Meng, Zhaofeng, Li, Lin, Yu, Shuangqing, Peng, Jifen, Guo, Haiyan, Xu |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Biomedical chromatography : BMC. 30(11) |
| ISSN: |
1099-0801 |
| Popis: |
Nitazoxanide (NTZ) is a broad-spectrum antimicrobial agent. Tizoxanide (T) and tizoxanide glucuronide (TG) are the major circulating metabolites after oral administration of NTZ. A rapid and specific LC-MS/MS method for the simultaneous quantification of T and TG in mouse plasma was developed and validated. A simple acetonitrile-induced protein precipitation method was employed to extract two analytes and the internal standard glipizide from 50 μL of mouse plasma. The purified samples were resolved using a C |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text