The Wanderings of Gut-Derived IgA Plasma Cells: Impact on Systemic Immune Responses
| Autor: | Keppler, Selina J., Goess, Marie Christine, Heinze, Julia M. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
animal diseases
Mini Review Immunology autoimmunity Plasma Cells chemical and pharmacologic phenomena biochemical phenomena metabolism and nutrition eye diseases Immunity Humoral Immunoglobulin A plasma cell (PC) Chemotaxis Leukocyte inflammation bacteria mucosal immunity Animals Humans IgA antibodies Intestinal Mucosa Immunity Mucosal gut-associated lymphoid tissues (GALT) |
| Zdroj: | Frontiers in Immunology |
| ISSN: | 1664-3224 |
| Popis: | Humoral immunity is mainly mediated by a B cell population highly specialized to synthesize and secrete large quantities of antibodies - the antibody-secreting cells (ASC). In the gastrointestinal environment, a mixture of foreign antigens from the diet, commensal microbiota as well as occasional harmful pathogens lead to a constant differentiation of B cells into ASC. Due to this permanent immune response, more than 80% of mammalian ASC reside in the gut, of which most express immunoglobulin A (IgA). IgA antibodies contribute to intestinal homeostasis and can mediate protective immunity. Recent evidence points at a role for gut-derived ASC in modulating immune responses also outside of mucosal tissues. We here summarize recent evidence for wandering ASC, their antibodies and their involvement in systemic immune responses. |
| Databáze: | OpenAIRE |
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