Sexually dimorphic activation of liver and brain phosphatidylethanolamine N-methyltransferase by dietary choline deficiency

Autor:	P I, Johnson, J K, Blusztajn
Rok vydání:	1998
Předmět:	Male Analysis of Variance Sex Characteristics Phosphatidylethanolamine N-Methyltransferase Brain Methyltransferases Choline Choline Deficiency Rats Enzyme Activation Rats Sprague-Dawley Liver Animals Female
Zdroj:	Neurochemical research. 23(5)
ISSN:	0364-3190
Popis:	Phosphatidylethanolamine N-methyltransferase (PEMT) activity was measured by a radioenzymatic assay in homogenates of brain and liver obtained from Sprague Dawley rats fed a choline-free or control (0.3 g/kg of choline chloride) diet for seven days. Choline deficiency increased PEMT activity in the liver of male rats by 34% but had no effect on hepatic PEMT in females. In contrast, brain PEMT activity was increased in brain of choline deficient females (by 49%) but was unaltered in males. Activation of the PE methylation pathway in female brain may constitute a compensatory mechanism to sustain PC synthesis during choline deficiency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::49dc884079ebc13c17593d9cb6a07312 https://pubmed.ncbi.nlm.nih.gov/9566595 Zobrazit plný text záznamu Full text from SpringerLink