| Autor: |
Faezeh, Azizi, Soraya, Saleh Gargari, Sedigheh, Asadi Shahmirzadi, Fatemeh, Dodange, Vahid, Amiri, Reza, Mirfakhraie, Mir Davood, Omrani |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
International Journal of Molecular and Cellular Medicine |
| ISSN: |
2251-9637 |
| Popis: |
It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PE is associated with alterations in placental non-coding RNAs expression. MicroRNA (miR)-155-5p and long non-coding RNA (lnc)sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR.The relationship between miR-155-5p and lncsONE expressions was analyzed statistically. miR-155-5p expression was increased (fold change =1.6, P=0.04), while lncsONE expression was not significantly changed (fold change =1.1, P=0.68), in placentas from patients compared with control group.miR-155-5p was upregulated in placentas from patients with PE and may have influenced eNOS expression. These findings indicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for this disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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