| Autor: |
M, Schirmer, E, Mur, K P, Pfeiffer, J, Thaler, G, Konwalinka |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Scandinavian journal of rheumatology. 26(5) |
| ISSN: |
0300-9742 |
| Popis: |
Cladribine (2-chlorodeoxyadenosine, 2-CdA) is a newer purine analog with specific toxicity to lymphocytes. As lymphocytes play a major role in rheumatoid arthritis (RA), we assessed the safety profile of low-dose 2-CdA in patients who were refractory to more than three disease-modifying drugs. Five patients were given a subcutaneous dosage of 0.05 mg/kg 2-CdA weekly over a period of 8 weeks. Of the lymphocyte subsets, both T and B cells decreased below the normal range, whereas natural killer cells remained stable. These changes were the only side-effects noted during treatment and 4 weeks afterwards. In one patient a pacemaker was implanted for reasons unlikely to be related to 2-CdA administration. We conclude that even low-dose 2-CdA (0.05 mg/kg) can decrease T and B cell populations in patients with refractory RA, but other side-effects are unlikely. For assessing the possible clinical efficacy of low-dose 2-CdA further studies are warranted. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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