Granulocytic macrophage colony stimulating factor restores in vitro growth of granulocyte-macrophage bone marrow hematopoietic progenitors in dyskeratosis congenita

Autor:	R, Michalevicz, S, Baron, U, Nordan, R, Rahmani
Rok vydání:	1989
Předmět:	Adult Male Pancytopenia Granulocyte-Macrophage Colony-Stimulating Factor Nails Malformed Syndrome Hematopoietic Stem Cells Tongue Neoplasms Colony-Stimulating Factors Bone Marrow Humans Leukoplakia Oral Growth Substances Pigmentation Disorders Cells Cultured
Zdroj:	Israel journal of medical sciences. 25(4)
ISSN:	0021-2180
Popis:	In vitro 14-day cultures of bone marrow from a patient with dyskeratosis congenita showed virtually no growth of colonies. The addition of recombinant granulocyte-macrophage colony stimulating factor (rGM-CSF) promoted a significant increase in the number of GM colonies (CFU-GM). Interleukin 3 also increased GM colony formation but to a lesser extent. GM-CSF may have a therapeutic implication for pancytopenia in dyskeratosis congenita.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::49b903af22e06d7cb3bfcaced64978c9 https://pubmed.ncbi.nlm.nih.gov/2651350 Zobrazit plný text záznamu