| Autor: |
C, Oliver, M, Grino, P, Moatti Vacher-Coponat, I, Morange, F, Retornaz |
| Jazyk: |
francouzština |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
La Revue de medecine interne. 38(11) |
| ISSN: |
1768-3122 |
| Popis: |
The non-adherence to substitutive treatment by L-thyroxine is the main cause of the discordance between high thyrotropin values and high doses of the drug.In a 36-year-old patient with post-surgery hypothyroidism, thyrotropin values ranged between 100 and 400 mUI/L, although daily replacement therapy included 300 μg of L-thyroxine and 75 μg of L-triiodothyronine. The oral loading test with L-thyroxine was normal and thyrotropin serum level returned to normal values under weekly oral administration of 1000 μg L-thyroxine.The strategy of non-adherence treatment in hypothyroidism is well defined with oral testing of L-thyroxine, followed by oral or parenteral weekly administration of the drug. The L-thyroxine oral test is the gold standard for diagnosis after eliminating of the other conventional causes: drug interactions or digestive malabsorption. L-thyroxine treatment should be discussed on a case-by-case basis, either daily under surveillance or once weekly oral or parenteral high dose. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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