| Autor: |
Sahra, St John-Campbell, James A, Bull |
| Rok vydání: |
2019 |
| Zdroj: |
Chemical communications (Cambridge, England). 55(62) |
| ISSN: |
1364-548X |
| Popis: |
Palladium catalysed β-C(sp3)-H activation of tertiary aldehydes using a transient imine directing group enables intramolecular arylation to form substituted indane-aldehydes. A simple amine bearing a methyl ether (2-methoxyethan-1-amine) is the optimal TDG to promote C-H activation and reaction with an unactivated proximal C-Br bond. Substituent effects are studied in the preparation of various derivatives. Preliminary mechanistic studies identify a reversible C-H activation, product inhibition and suggest that oxidative addition is the turnover limiting step. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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