Effect of beta-amyloid peptide fragment 25-35 on nonselective permeability of mitochondria

Autor:	E F, Shevtzova, E G, Kireeva, S O, Bachurin
Rok vydání:	2002
Předmět:	Neurons Amyloid beta-Peptides Time Factors Dose-Response Relationship Drug Epinephrine Dopamine Brain Cytochrome c Group Intracellular Membranes Peptide Fragments Mitochondria Rats Norepinephrine Liver Pyruvic Acid Cyclosporine Lactates Animals Calcium Lipid Peroxidation Rats Wistar
Zdroj:	Bulletin of experimental biology and medicine. 132(6)
ISSN:	0007-4888
Popis:	Beta-amyloid peptide fragment 25-35 potentiated phosphate- and calcium-induced opening of mitochondrial channels and caused swelling of mitochondria (even without exogenous calcium and phosphate). These changes were accompanied by accumulation of lipid peroxidation products in mitochondria. Specific inhibitors of mitochondrial channels ADP and cyclosporine A prevented beta-amyloid peptide-induced swelling of mitochondria. Our findings suggest that potentiation of mitochondrial channel opening is an important component of the neurodegenerative effect of beta-amyloid.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::49611c87d37722115ee390f1cafc82d5 https://pubmed.ncbi.nlm.nih.gov/12152879 Zobrazit plný text záznamu Full text from SpringerLink