Meta-analysis of passive immunoprophylaxis in paediatric patients at risk of severe RSV infection

Autor:	J M V, Pons, C, Tebé, N, Paladio, A, Garcia-Altes, I, Danés, A, Valls-I-Soler
Rok vydání:	2010
Předmět:	Immunization Passive Antibodies Monoclonal Humans Infant Respiratory Syncytial Virus Infections Risk Assessment Severity of Illness Index Randomized Controlled Trials as Topic
Zdroj:	Acta paediatrica (Oslo, Norway : 1992). 100(3)
ISSN:	1651-2227
Popis:	To review respiratory syncytial virus (RSV), passive immunoprophylaxis (PI) trials and meta-analysis (MA).A literature review.Two MA of PI were found. Overall 3927 patients were randomized. PI reduces RSV hospitalization in patients with bronchopulmonary dysplasia (RR 0.58; 95% CI 0.41, 0.82) and with acyanotic congenital heart disease (RR 0.29; 95% CI 0.14, 0.62). In patients with cyanotic heart disease or premature infants without bronchopulmonary dysplasia, results are inconclusive. Passive immunoprophylaxis has a null effect in mechanical ventilation and death.Passive immunoprophylaxis reduces RSV hospitalization in a subset of patients. However, it has no effect in harder endpoints of RSV disease severity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4945dc570359c26e8891bfd7cbcf04bd https://pubmed.ncbi.nlm.nih.gov/20950412 Zobrazit plný text záznamu Plný text