| Popis: |
The glycerol from biodiesel as a valuable by-product can be used as food supplements in feed for animals. We investigated the effect of this by-product on metabolism in mice.CBA/CA mice were administered purified glycerol products (called SZME3) for 3, 6 and 24 hours. After dietary exposure, gene expressions of cytochrome P450, family 1, subfamily a polypeptide 1 (Cyp1a1) and cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1) were analysed in liver.SZME3 induced an up-regulation of both genes in both genders after three hours' administration. After longer administration of SZME3, the expression of genes became similar to that of the controls.Based upon our data SZME3 has no long-term effect on oxidative metabolism, it seems not to cause oxidative stress for liver cells. |
