| Autor: |
J C, Britell, C G, Moertel, L K, Kvols, M J, O'Connell, J, Rubin, A J, Schutt |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
Cancer treatment reports. 65(9-10) |
| ISSN: |
0361-5960 |
| Popis: |
Oral 6-thioguanine (6-TG) is an S-phase antimetabolite with significant activity against acute leukemia. Preliminary reports of activity of iv 6-TG indicated significant activity against advanced colorectal cancer. We conducted a phase II study of iv 6-TG in 29 patients with advanced measurable colorectal cancer. Only one transient partial response occurred. Toxic effects included mild myelosuppression, nausea, vomiting, and minor ECG changes. We discourage further use of iv 6-TG in the dose and schedule we used to treat advanced colorectal cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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