| Autor: |
Isabel, Diebold, Damir, Kraicun, Steve, Bonello, Agnes, Görlach |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Thrombosis and haemostasis. 100(6) |
| ISSN: |
0340-6245 |
| Popis: |
Vascular remodelling is a complex phenomenon associated with restructuring of the vessel wall as a consequence of disruption of vascular homeostasis. Alterations of the vascular wall have been linked to a variety of cardiovascular disorders including atherosclerosis, vascular injury and pulmonary hypertension. Plasminogen activator inhibitor-1 (PAI-1) is a member of the serpin (serine proteinase inhibitor) family and acts as an important inhibitor of fibrinolysis by interfering with the plasminogen system. In addition to its anti-fibrinolytic effects, PAI-1 appears to modulate cellular responses linked to vascular remodelling. Since PAI-1 levels have been shown to be altered in various disorders associated with vascular remodelling of the systemic and pulmonary vascular bed, this serpin may play a pivotal role in the pathogenesis of these diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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