[Pediatric glioblastoma: a clinicopathological study of 12 cases with p53 protein immunohistochemistry]

Autor:	Leonora Zozula Blind, Pope, Maria José, Serapião, Carlos José, Serapião, Maria Marcelina Silva Teive, Oliveira, Paulo Roberto, Benites Filho, Elizabeth Scheneider, Gugelmin, Luiz Fernando, Bleggi-Torres
Rok vydání:	2007
Předmět:	Male Brain Neoplasms Child Preschool Biomarkers Tumor Infant Newborn Humans Infant Female Tumor Suppressor Protein p53 Child Glioblastoma Immunohistochemistry Survival Analysis
Zdroj:	Arquivos de neuro-psiquiatria. 65(4A)
ISSN:	0004-282X 1987-2003
Popis:	Glioblastoma is one of the most lethal central nervous system (CNS) primary tumors. Although significant progress, only few analysis have been made in pediatric glioblastoma, which are less common and have worse prognosis than in adults. To evaluate gender, site, age, survival, and immunohistochemistry to p53, we selected cases of pediatric glioblastoma of "CNS Tumors Database in Curitiba", 1987-2003 and of the Hospital Municipal Jesus, Rio de Janeiro, 1970-1988. Twelve tumors were included. The age ranged from up to 12 years (median 7). There were 7 females and 5 males. The median survival was 7.9 months. Location was: cerebral hemispheres (58.4%), mesencephalon and brainstem (33.3%) and one case in the cerebellum. Immunostained to p53 in 9 (75%) cases. In conclusion, glioblastoma behaves similarly in children and adults. It is rare in children, affects both cerebral hemispheres more than brainstem and cerebellum and shows strong immunohistochemistry to p53.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::48f763ea033a60de163286d73a7a61cf https://pubmed.ncbi.nlm.nih.gov/18094877 Zobrazit plný text záznamu