Maternal glucose intolerance reduces offspring nephron endowment and increases glomerular volume in adult offspring

Autor:	Stacey, Hokke, Nicole, Arias, James A, Armitage, Victor G, Puelles, Karen, Fong, Stefania, Geraci, Norbert, Gretz, John F, Bertram, Luise A, Cullen-McEwen
Rok vydání:	2015
Předmět:	Mice Knockout Fetal Growth Retardation Kidney Glomerulus Maternal Nutritional Physiological Phenomena Nephrons Embryo Mammalian Weight Gain Mice Inbred C57BL Diabetes Gestational Mice Pregnancy Prenatal Exposure Delayed Effects Glucose Intolerance Animals Receptors Leptin Female
Zdroj:	Diabetes/metabolism research and reviews. 32(8)
ISSN:	1520-7560
Popis:	Animal studies report a nephron deficit in offspring exposed to maternal diabetes, yet are limited to models of severe hyperglycaemia which do not reflect the typical clinical condition and which are associated with foetal growth restriction that may confound nephron endowment. We aimed to assess renal morphology and function in offspring of leptin receptor deficient mice (LeprNephron endowment was assessed in offspring of C57BKS/J LeprCompared with +/+ dams, LeprIGT throughout gestation resulted in a nephron deficit that was established early in renal development. Maternal IGT was associated with glomerular hypertrophy in adult offspring, likely a compensatory response to maintain normal renal function. Given the increasing prevalence of IGT, monitoring glucose from early in gestation may be important to prevent altered kidney morphology. Copyright © 2016 John WileySons, Ltd.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::48e199bd6bcab9d9a313a1c85a64c595 https://pubmed.ncbi.nlm.nih.gov/27037899 Zobrazit plný text záznamu Plný text