| Autor: |
Katherine, Beck, Atheeshaan, Arumuham, Stefan, Brugger, Robert A, McCutcheon, Mattia, Veronese, Barbara, Santangelo, Colm J, McGinnity, Joel, Dunn, Stephen, Kaar, Nisha, Singh, Toby, Pillinger, Faith, Borgan, Teresa, Sementa, Radhouene, Neji, Sameer, Jauhar, Franklin, Aigbirhio, Istvan, Boros, Federico, Turkheimer, Alexander, Hammers, David, Lythgoe, James, Stone, Oliver D, Howes |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of psychopharmacology (Oxford, England). 36(9) |
| ISSN: |
1461-7285 |
| Popis: |
Evidence from post-mortem studies and in vivo imaging studies suggests there may be reducedIn this study, we investigated the relationship between hippocampal NMDAR and striatal glutamate using simultaneous positron emission tomography-magnetic resonance (PET-MR) imaging. We recruited 40 volunteers to this cross-sectional study; 21 patients with schizophrenia, all in their first episode of illness, and 19 healthy controls. We measured hippocampal NMDAR availability using the PET ligand [A total of 33 individuals (15 healthy controls, 18 patients) were included in the analyses (mean (SD) age of controls, 27.31 (4.68) years; mean (SD) age of patients, 24.75 (4.33), 27 male and 6 female). We found an inverse relationship between hippocampal DVR and striatal glutamate levels in people with first-episode psychosis (rho = -0.74,This study show that lower relative NMDAR availability in the hippocampus may drive increased striatal glutamate levels in patients with schizophrenia. Further work is required to determine whether these findings may yield new targets for drug development in schizophrenia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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