| Popis: |
To assess the efficacy and safety of 3% mepivacaine hydrochloride injection for oral local anesthesia.68 non-hypertension patients and 36 hypertension patients were randomly divided into 2 groups for local anesthesia. 2% lidocaine with adrenaline in same cartridge was as control group and 3% mepivacaine was as the experimental group. The onset time,duration and pain-free time of 2 anaesthetics were examined. The blood pressure and heart rate change, neural reaction and side effect of 2 groups were observed. SAS software package was used for statistical analysis.In the mepivacaine group, the average onset time was 111s, the duration time was 212s and pain-free time was 134 min ,which was similar to those of 2% lidocaine. Immediately after injection, 5 minutes and 10 minutes after injection of anesthesia, and post-operation, there were no significant changes in the systolic blood pressures between 2% lidocaine group and 3% mepivacaine group (P0.05), but there were significant changes in diastolic blood pressures and heart rate (P0.05).3% mepivacaine has quick onset, ideal anesthetic effect and little side effect on cardiovascular system. |
