| Autor: |
Pei-Gen, Yuan, Bin-Bin, Xue, Bi, Lin, Xi-Yue, Zhao, Sen, Zhou, Yi, Hu, Cai-Ying, Bao, Li-Na, Lin |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 32(3) |
| ISSN: |
1000-6834 |
| Popis: |
To explore the role of Nrf2/ARE pathway in skeletal muscle ischemia/reperfusion(I/R) injury preconditioning by dexmedetomidine(DEX).Twenty-eight SD rats were randomly divided into sham-operated(Sham group)、I/R group、I/R+ DEX(DEX group) and I/R+DEX +Atipamezole (Atip group). In the Atip group, Atip(250The levels of wet/dry、MDA、LDH、CK、Nrf2 and HO-1 were higher(Nrf2 protein was expressed in skeletal muscle of rat and DEX could promote its level in nucleus by α-adrenergic receptor. The down-stream products of Nrf2 have the effect of antioxidant. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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