Monocytes and Macrophages in Alpha-1 Antitrypsin Deficiency
| Autor: | Belchamber, Kylie B R, Walker, Eloise M, Stockley, Robert A, Sapey, Elizabeth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
alpha-1 antitrypsin deficiency
congenital hereditary and neonatal diseases and abnormalities Macrophages Review macrophage Monocytes respiratory tract diseases Pulmonary Disease Chronic Obstructive Pulmonary Emphysema alpha 1-Antitrypsin alpha 1-Antitrypsin Deficiency monocyte Humans alpha-1 antitrypsin |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 1176-9106 |
| Popis: | Alpha-1 antitrypsin deficiency (AATD) is a genetic condition characterised by low circulating levels of alpha-1 antitrypsin (AAT), a serine proteinase inhibitor. The most common deficiency variants are the S and Z mutations, which cause the accumulation of misfolded AAT in hepatocytes resulting in endoplasmic reticular stress and insufficient release of AAT into the circulation ( |
| Databáze: | OpenAIRE |
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