| Autor: |
R F, Meredith, A J, Bueschen, M B, Khazaeli, W E, Plott, W E, Grizzle, R H, Wheeler, J, Schlom, C D, Russell, T, Liu, A F, LoBuglio |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 35(6) |
| ISSN: |
0161-5505 |
| Popis: |
A Phase II trial of 75 mCi/m2 131I-anti-TAG-72 high-affinity antibody CC49 was studied in 15 patients with hormone-resistant metastatic prostate cancer.Patients had adequate renal, liver and hematopoietic function. No previous cytotoxic chemotherapy was allowed and previous radiation was limited to 20% of the active bone marrow.No acute adverse reactions occurred, but all patients had evidence of an immune response to CC49 by 4 wk. Six of 10 symptomatic patients had bone pain relief, but no patients met the radiographic or PSA criteria for objective response. Positive imaging of bone and/or soft-tissue lesions was noted for 13 of the 15 patients.CC49 had a high frequency of tumor localization with evidence of anti-tumor effects (pain relief). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
