Comparison of Frequency and Duration of Periodontal Disease with Progression of Coronary Artery Calcium in Patients with Type 1 Diabetes Mellitus versus Non-Diabetics
| Autor: | Groves, Daniel W., Krantz, Mori J., Hokanson, John E., Johnson, Lonnie R., Eckel, Robert H., Kinney, Gregory L., Rewers, Marian, Snell-Bergeon, Janet K., Alman, Amy C. |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Time Factors nutritional and metabolic diseases Coronary Artery Disease Middle Aged Article Cohort Studies Diabetes Mellitus Type 1 Logistic Models Case-Control Studies Hypertension Multivariate Analysis Disease Progression Prevalence Humans Female Prospective Studies Tomography X-Ray Computed Vascular Calcification Periodontal Diseases Dyslipidemias |
| Popis: | People with type 1 diabetes mellitus manifest a higher burden of both periodontal disease and coronary artery disease (CAD); however, little is known about their interrelation. Coronary artery calcium (CAC) measures subclinical atherosclerosis and predicts major adverse coronary events. The relation between periodontal disease and CAC progression in individuals with type 1 diabetes has not been previously described. We determined the prevalence and progression of CAC in relation to self-reported periodontal disease. Multivariate logistic and tobit regression models were used to examine the relation between periodontal disease duration and CAC progression and whether this relation differs by diabetes status after controlling for age, sex, total and high-density lipoprotein (HDL) cholesterol, hypertension, smoking, body mass index (BMI), duration of diabetes, and baseline CAC. A total of 473 individuals with type 1 diabetes and 548 non-diabetic individuals were followed for a mean of 6.1 years. At baseline, the prevalence and duration of periodontal disease did not differ between individuals with and without diabetes (14.5% vs. 13.4%, p=0.60; 6 vs. 9 years, p=0.18). Duration of periodontal disease was not significantly associated with baseline CAC prevalence. In type 1 diabetic individuals, periodontal disease duration was significantly related to CAC progression (p=0.004) but not among non-diabetic individuals (p=0.63). In conclusion, this study suggests that periodontal disease is an independent predictor of long-term progression of CAC in type 1 diabetic individuals. |
| Databáze: | OpenAIRE |
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