Genome-wide association study of primary dysmenorrhea in the Taiwan Biobank validates associations near the NGF and IL1 gene loci

Autor:	Chien-Chang, Lee, Meng-Tse Gabriel, Lee, I-Hsuan, Huang, Jasmine, Tan, Zachary R, McCaw, Ke-Ying, Su, Tzu-Chun, Hsu, Ruby Y J, Huang, Po-Hsiu, Kuo, Shyr-Chyr, Chen, Chung-Yen, Huang
Rok vydání:	2021
Předmět:	Dysmenorrhea Interleukin-1alpha Interleukin-1beta Nerve Growth Factor Taiwan Humans Female Genetic Predisposition to Disease Polymorphism Single Nucleotide Biological Specimen Banks Genome-Wide Association Study
Zdroj:	Journal of human genetics. 67(8)
ISSN:	1435-232X
Popis:	Using the Taiwan Biobank, we aimed to identify traits and genetic variations that could predispose Han Chinese women to primary dysmenorrhea. Cases of primary dysmenorrhea included those who self-reported "frequent dysmenorrhea" in a dysmenorrhea-related Taiwan Biobank questionnaire, and those who have been diagnosed with severe dysmenorrhea by a physician. Controls were those without self-reported dysmenorrhea. Customized Axiom-Taiwan Biobank Array Plates were used to perform whole-genome genotyping, PLINK was used to perform association tests, and HaploReg was used to conduct functional annotations of SNPs and bioinformatic analyses. The GWAS analysis included 1186 cases and 24,020 controls. We identified 53 SNPs that achieved genome-wide significance (P 5 × 10
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4875bc3402f3705eb3260f6d8cea9aa7 https://pubmed.ncbi.nlm.nih.gov/35351958 Zobrazit plný text záznamu Full text from SpringerLink