| Autor: |
Bela, Joos, Benjamin M, Barlow, Catherine E, Morris |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Handbook of experimental pharmacology. 246 |
| ISSN: |
0171-2004 |
| Popis: |
Two features common to diverse sick excitable cells are "leaky" Nav channels and bleb damage-damaged membranes. The bleb damage, we have argued, causes a channel kinetics based "leakiness." Recombinant (node of Ranvier type) Nav1.6 channels voltage-clamped in mechanically-blebbed cell-attached patches undergo a damage intensity dependent kinetic change. Specifically, they experience a coupled hyperpolarizing (left) shift of the activation and inactivation processes. The biophysical observations on Nav1.6 currents formed the basis of Nav-Coupled Left Shift (Nav-CLS) theory. Node of Ranvier excitability can be modeled with Nav-CLS imposed at varying LS intensities and with varying fractions of total nodal membrane affected. Mild damage from which sick excitable cells might recover is of most interest pathologically. Accordingly, Na |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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