Relapse status as a prognostic factor in patients receiving salvage surgery for recurrent or residual nasopharyngeal cancer after definitive treatment
Autor: | Jeremy, Chee, Yohanes, Ting, Yew Kwang, Ong, Siew Shuen, Chao, Kwok Seng, Loh, Chwee Ming, Lim |
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Rok vydání: | 2015 |
Předmět: |
Adult
Male Salvage Therapy Analysis of Variance Singapore Nasopharyngeal Carcinoma Neoplasm Residual Carcinoma Nasopharyngeal Neoplasms Kaplan-Meier Estimate Middle Aged Prognosis Risk Assessment Survival Analysis Disease-Free Survival Cohort Studies Treatment Outcome Nasopharynx Multivariate Analysis Humans Female Neoplasm Recurrence Local Aged Proportional Hazards Models Retrospective Studies |
Zdroj: | Headneck. 38(9) |
ISSN: | 1097-0347 |
Popis: | The purpose of this study was to determine the prognostic value of relapse status (recurrent vs residual disease) in patients receiving surgical salvage for nasopharyngeal carcinoma (NPC).Retrospective review was conducted on 52 patients who underwent salvage surgery for locoregional relapse of NPC. Univariate and multivariate analyses were used to investigate the prognostic value of relapse status.Median follow-up duration was 44.4 months. Mean overall survival (OS) and disease-free survival (DFS) for patients with NPC with residual and recurrent disease after surgical salvage were 107.4 and 54.4 months, and 83.6 and 34.6 months, respectively (p.001). This improved survival was demonstrated regardless whether the relapse was at the primary or nodal site. Multivariate analysis revealed that recurrent disease status and nodal disease relapse were independent poor prognostic factors for survival in patients receiving salvage surgery for NPC.In patients undergoing surgical salvage for NPC relapse, residual disease carries a better prognosis than recurrent disease. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1393-1400, 2016. |
Databáze: | OpenAIRE |
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