| Autor: |
Michelle M, Sonsalla, Santidra L, Love, Laurana J, Hoh, Lauren N, Summers, Hannah M, Follett, Aminata, Bojang, Khrystyne N, Duddleston, Courtney C, Kurtz |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 191(5) |
| ISSN: |
1432-136X |
| Popis: |
Obesity is a worldwide pandemic with significant comorbidities. It is often accompanied by mild inflammation of the intestine followed by inflammation of metabolic tissues such as liver, adipose tissue, and skeletal muscle. Several laboratory models of obesity exist, but seasonal models like hibernators may be valuable for understanding the pathogenesis of obesity independent of genetic or high-fat diet-induced changes. As part of their annual cycle, obligate hibernators, like the 13-lined ground squirrel (Ictidomys tridecemlineatus), undergo a rapid shift from a lean to an obese state to store energy in the form of fat for their prolonged winter fast. Here, we show that ground squirrels gained mass steadily throughout the active season despite a drop in energy intake starting around 9 weeks post-hibernation. Glucose tolerance tests revealed a significant decrease in tolerance late in the active season. In visceral adipose, we found increases in adipocyte size, tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels. IL-6 levels also increased in liver and muscle and TNF-α increased in the ileum late in the active season. Levels of the anti-inflammatory cytokine, IL-10, decreased in visceral adipose and colon tissues around the same time. These data suggest metabolic inflammation develops along with adiposity late in the squirrels' active season. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink