| Autor: |
Pawel V, Lipinsky, Ivan V, Sirotin, Alexandr V, Skoroglyadov, Alexey V, Ivkov, Alexandr P, Oettinger, Evgeny E, Krynetskiy, Alexandr B, But-Gusaim, Andreas J, Roth |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
BMC Musculoskeletal Disorders |
| ISSN: |
1471-2474 |
| Popis: |
Background Recent research has focused on identifying chemical modulators of osteogenesis. We present initial findings on the osteoinductive properties of prostaglandin Е1 (Vasaprostan), using a rabbit model. Methods Data were collected on callus formation in 14 male rabbits. These were divided into two groups (control and treatment) with 7 animals in each group. In all animals, the right tibia was fractured using a standardized protocol and stabilized by an intramedullary nail. Treatment group received a 5 μg/kg subcutaneous injection of PGE1/day during 10 postoperative days. Visual and radiological evaluation of callus formation was prospectively collected. After 30 days, all animals were killed and the tibia specimens were examined histologically. Results In all the treatment group animals, fractures were consolidated radiologically by day 30. No treatment group animals and two control group animals were excluded form the experiment. In the control group, 4 animals demonstrated slower callus formation than the main group. Two control group animals were excluded from the experiment on the 20th day due to wound infection; one developed a nonunion. The mean coefficient of bone callus thickening in the main group was 2.08 (±0, 16) and 1.77 (±0.05) (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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