[Occupational exposure to respiratory irritants and chronic obstructive pulmonary disease]
| Autor: | S, Quintavalle, L, Mazzetti, E, Zeni, N, Lo Cascio, S, Leprotti, L, Ballerin, A, Potena, C E, Mapp, E, De Rosa, P, Boschetto |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Time Factors Tissue Inhibitor of Metalloproteinase-1 Neutrophils Smoking Sputum Cell Count Respiratory Function Tests Occupational Diseases Pulmonary Disease Chronic Obstructive Pulmonary Emphysema Risk Factors Occupational Exposure Irritants Metalloproteases Humans Female Radiography Thoracic Tomography X-Ray Computed Aged |
| Zdroj: | Giornale italiano di medicina del lavoro ed ergonomia. 27(3) |
| ISSN: | 1592-7830 |
| Popis: | Cigarette smoking and occupational exposure to respiratory irritants are the major riskfactors for chronic obstructive pulmonary disease (COPD), which is characterized by small-airway obstruction and destruction of pulmonary parenchyma: emphysema. We studied two groups of subjects: one exposed and the other one not-exposed to respiratory irritants, to investigate the relationship, if any, between occupational exposure and COPD. Subjects underwent high-resolution computed tomography-density mask of the chest to quantify pulmonary emphysema, pulmonary function tests, sputum induction and analysis for cell counts and measurements of metalloproteinase (MMP)-9 and its tissue inhibitor TIMP-1. Subjects with occupational exposure to respiratory irritants had higher residual volume and functional residual capacity, higher total inflammatory cells and neutrophils in induced sputum. By contrast, sputum levels of MMP-9, TIMP-1 and MMP-91TIMP-1 ratio did not differ between the 2 groups. We conclude that sputum induction and analysis could be a useful and non-invasive tool to study and follow subjects with occupational exposure to respiratory irritants. |
| Databáze: | OpenAIRE |
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