| Autor: |
Mariana F B, Gerzson, Simone M, Pacheco, Mayara S P, Soares, Natália P, Bona, Pathise S, Oliveira, Juliana H, Azambuja, Pauline, da Costa, Jessié M, Gutierres, Fabiano B, Carvalho, Vera M, Morsch, Roselia M, Spanevello, Francieli M, Stefanello |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Archives of physiology and biochemistry. 128(1) |
| ISSN: |
1744-4160 |
| Popis: |
The aim of this study was to investigate the ability of tannic acid (TA) in preventing memory deficits and neurochemical alterations observed in a model for Sporadic Dementia of Alzheimer's Type. Rats were treated with TA (30 mg/kg) daily for 21 days, and subsequently received intracerebroventricular injection of streptozotocin (STZ). We observed that STZ induced learning and memory impairments; however, treatment with TA was able to prevent these effects. In cerebral cortex and hippocampus, STZ induced an increase in acetylcholinesterase activity, reduced Na |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
