Mucoactive agents for chronic, non-cystic fibrosis lung disease: A systematic review and meta-analysis

Autor:	Benjamin J, Tarrant, Caitlin, Le Maitre, Lorena, Romero, Ranjana, Steward, Brenda M, Button, Bruce R, Thompson, Anne E, Holland
Rok vydání:	2016
Předmět:	Lung Diseases Saline Solution Hypertonic Vital Capacity Symptom Flare Up Recombinant Proteins Acetylcysteine Bronchiectasis Mucociliary Clearance Forced Expiratory Volume Administration Inhalation Chronic Disease Quality of Life Deoxyribonuclease I Humans Mannitol Expectorants Mesna
Zdroj:	Respirology (Carlton, Vic.). 22(6)
ISSN:	1440-1843
Popis:	Inhaled mucoactive agents are used in respiratory disease to improve mucus properties and enhance secretion clearance. The effect of mannitol, recombinant human deoxyribonuclease/dornase alfa (rhDNase) and hypertonic saline (HS) or normal saline (NS) are not well described in chronic lung conditions other than cystic fibrosis (CF). The aim of this review was to determine the benefit and safety of inhaled mucoactive agents outside of CF. We searched Medline, Embase, CINAHL and CENTRAL for randomized controlled trials investigating the effects of mucoactive agents on lung function, adverse events (AEs), health-related quality of life (HRQOL), hospitalization, length of stay, exacerbations, sputum clearance and inflammation. There were detrimental effects of rhDNase in bronchiectasis, with average declines of 1.9-4.3% in forced expiratory volume in 1 s (FEV
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::48008d76e164fa2c721c9c7aaf381841 https://pubmed.ncbi.nlm.nih.gov/28397992 Zobrazit plný text záznamu Plný text