[The anti-arrhythmia action of combinations of N-propylajmaline bromide with anti-arrhythmia agents of different classes]

Autor:	E I, Gendenshteĭn, V P, Balashov, Ia V, Kostin, V E, Oleĭnikov
Rok vydání:	1990
Předmět:	Ajmaline Cardiac Complexes Premature Dogs Dose-Response Relationship Drug Prajmaline Drug Evaluation Preclinical Myocardial Infarction Animals Drug Synergism Drug Therapy Combination Anti-Arrhythmia Agents
Zdroj:	Farmakologiia i toksikologiia. 53(1)
ISSN:	0014-8318
Popis:	In experiments on 68 dogs with ventricular arrhythmia at the late stage of experimental myocardial infarction caused by the coronary artery branch occlusion it was shown that combinations of N-propylaimaline bromide (IA class of antiarrhythmic agents) with trimecaine (IB class) or anapriline (II class) or phynoptine (IV class) induce a significant increase of the antiarrhythmic effect that is not observed at combination of N-propylaimaline with ethmosine (the both antiarrhythmic drugs belong to IA class). This potentiating effect is thought to be related to differences in the molecular mechanisms of action of antiarrhythmic drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::47fc864fc98e2571275e5bb5d550701d https://pubmed.ncbi.nlm.nih.gov/1691716 Zobrazit plný text záznamu