Function and regulation of ABCA1--membrane meso-domain organization and reorganization

Autor:	Kohjiro, Nagao, Maiko, Tomioka, Kazumitsu, Ueda
Rok vydání:	2011
Předmět:	Protein Transport Apolipoproteins Cholesterol Membrane Microdomains Gene Expression Regulation Mutation Animals Homeostasis Humans ATP-Binding Cassette Transporters Protein Processing Post-Translational Tangier Disease ATP Binding Cassette Transporter 1
Zdroj:	The FEBS journal. 278(18)
ISSN:	1742-4658
Popis:	The ATP-binding cassette protein A1 (ABCA1) mediates the secretion of cellular-free cholesterol and phospholipids to an extracellular acceptor, apolipoprotein A-I, to form high-density lipoprotein. Because ABCA1 is a key factor in cholesterol homeostasis, elaborate transcriptional and post-transcriptional regulations of ABCA1 have evolved to maintain cholesterol homeostasis. Recent studies suggest that ABCA1 moves lipids not only between membranes but also within membranes to organize and reorganize membrane meso-domains to modulate cell proliferation and immunity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::47e5dd75f0c7349b13e60687e5e8d354 https://pubmed.ncbi.nlm.nih.gov/21554545 Zobrazit plný text záznamu Plný text