Results of 206 isolated limb perfusions for malignant melanoma
| Autor: | F J, Lejeune, D, Liénard, M, el Douaihy, J V, Seyedi, P, Ewalenko |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Aged 80 and over Male Leg Adolescent Hyperthermia Induced Middle Aged Combined Modality Therapy Postoperative Complications Chemotherapy Cancer Regional Perfusion Lymphatic Metastasis Axilla Arm Humans Lymph Node Excision Female Neoplasm Recurrence Local Child Melanoma Melphalan Aged Neoplasm Staging |
| Zdroj: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 15(6) |
| ISSN: | 0748-7983 |
| Popis: | Between 1976 and 1988, 182 patients--135 females (74.3%) and 47 males (25.7%)--were submitted to 206 isolation perfusions, using melphalan and mild hyperthermia for 34 upper and 172 lower limbs. Stage I melanoma represented 37.4% including 75.4% greater than 1.5 mm Breslow thickness or with regression, ulceration or incisional biopsy. Stage II melanoma included 62.6% of the cases. Peri-operative mortality occurred in 2/182 patients. Amputation was performed within 1 month for toxic reasons in three patients and delayed in six for progressive disease. Regional toxicity consisted in oedema (76%), pain (61%), nerve palsy (24%), thrombosis (7%), septicemia (3%), thrombocyto-granulopenia (1.5%), minor miscellaneous (52%). Mean peripheral leakage was 1.0, 7.8 and 12.4% at respectively 5, 10 and 60 minutes. Projected 5-year disease-free survival was 79% for Stage I and 27% for Stage II. Survival at 5 years was 92% in Stage I and 53.5% in Stage II. Twenty-five patients were perfused twice for recurrence or incomplete response. Although the median disease-free interval was only about 8 months, the 5-year survival was 67%. This may indicate that isolation perfusion renders melanoma metastases less aggressive despite the fact they may recur at a high rate. |
| Databáze: | OpenAIRE |
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