[Regression of left ventricular hypertrophy and improvement of its diastolic function in patients with arterial hypertension under influence of antihypertensive therapy]
| Autor: | N V, Borzova, A A, Gorbachenkov |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Adolescent Dose-Response Relationship Drug Heart Ventricles Blood Pressure Recovery of Function Middle Aged Myocardial Contraction Echocardiography Doppler Ventricular Function Left Treatment Outcome Diastole Hypertension Humans Female Hypertrophy Left Ventricular Prospective Studies Antihypertensive Agents Follow-Up Studies |
| Zdroj: | Kardiologiia. 48(6) |
| ISSN: | 0022-9040 |
| Popis: | Antihypertensive therapy with sequential addition of drugs (noliprel, noliprel-forte, metoprolol, amlodipine) for achievement of target blood pressure (BP) below 140/90 mm Hg was used in the treatment of 99 patients with arterial hypertension (AH) with (n=51) or without left ventricular (LV) hypertrophy (LVH). At initial Doppler study of transmitral blood flow all patient with LVH had type 1 (n=48) or type 2 (n=3) diastolic LV dysfunction. Among patients without LVH 13 had minor type 1 diastolic LV dysfunction. After 12 - 14 months of antihypertensive therapy in all 44 patients with moderate LVH (myocardial mass index below 140 g/m2) BP corresponded to target level. This was associated with 6% decrease of myocardial mass index (MMI) and its normalization in 2/3 of patients, restoration of diastolic function in 3/4 of patients and its improvement in other patients, decrease of functional class, in rease of 6 min walking distance, and improvement of quality of life according to questionnaire for patients with CHF. In 7 patients with pronounced LVH (MMI 140 g/m2) target BP was not achieved, LVMMI, diastolic function, and functional class did not change, however tolerance to physical effort and quality of life improved. Thus in all patients with AH without LVH target BP level was achieved. In minor initial diastolic dysfunction diastolic function restored to normality, functional class, tolerance to physical work and quality of life improved. |
| Databáze: | OpenAIRE |
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