| Autor: |
D, Yamamoto, R D, Pinnock, D B, Sattelle |
| Rok vydání: |
2009 |
| Zdroj: |
Journal of neuroendocrinology. 1(2) |
| ISSN: |
0953-8194 |
| Popis: |
Single channel recordings of Ca(2+)-activated K(+) currents were made from dissociated cockroach neurons by means of the gigaohm-seal patch-clamp technique. Bursts of single channel openings were composed of two distinct classes: the 'long-open burst' contained groups of long, rectangular, pulse-like openings with durations of 3.5 to 1.2 ms (depending on membrane potential), whereas the 'flickering burst' consisted of clusters of brief openings with an average duration of 0.4 ms (voltage-independent) separated by short closings with a duration of about 1.0 ms. The long-open burst and the flickering burst appeared to reflect distinct states of a single Ca(2+)-activated K(+) channel because direct transitions between these two types of burst were often detected. We present a kinetic scheme for the gating activation pathway of a neuronal Ca(2+)-activated K(+) channel, based on these findings. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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