| Autor: |
Clare F, McCoy, David C, Apperley, Bruce, Variano, Heather, Sussman, Daniel, Loeven, Peter, Boyd, R Karl, Malcolm |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
International journal of pharmaceutics. 548(1) |
| ISSN: |
1873-3476 |
| Popis: |
Steroid molecules have a long history of incorporation into silicone elastomer materials for controlled release drug delivery applications. Previously, based on in vitro release testing and drug content analysis, we demonstrated indirectly that the contraceptive progestin levonorgestrel (LNG) chemically and irreversibly binds to addition cure silicone elastomers, presumably via a hydrosilylation reaction between the levonorgestrel ethynyl group and the hydrosilane groups in the poly(dimethylsiloxane-co-methylhydrosiloxane) crosslinker of the silicone elastomer. Here, for the first time, we report that solid state |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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