Double-blind comparative study of droperidol, granisetron and granisetron plus dexamethasone as prophylactic anti-emetic therapy in patients undergoing abdominal, gynaecological, breast or otolaryngological surgery

Autor:	R, Janknegt, J W, Pinckaers, M H, Rohof, M E, Ausems, M E, Arbouw, R W, van der Velden, J R, Brouwers
Rok vydání:	1999
Předmět:	Adult Male Anesthesia General Middle Aged Dexamethasone Granisetron Treatment Outcome Double-Blind Method Postoperative Nausea and Vomiting Antiemetics Humans Droperidol Drug Therapy Combination Female
Zdroj:	Anaesthesia. 54(11)
ISSN:	0003-2409
Popis:	In this double-blind study the clinical efficacy of a single pre-operative intravenous dose of droperidol 1.25 mg (137 patients), granisetron 1 mg (130 patients) and granisetron 1 mg plus dexamethasone 5 mg (130 patients) was investigated for the prevention of postoperative nausea and vomiting after gynaecological surgery, breast surgery, abdominal surgery and ear, nose and throat surgery. The incidence of nausea in the first 24 h postoperatively was 52% in the droperidol group, 48% in the granisetron group and 34% with the combination, respectively. Both granisetron and granisetron/dexamethasone performed better than droperidol in their effects on vomiting or combined nausea and vomiting (incidence in the first 24 h 22%, 18% and 42%, respectively). The number of emetic episodes during the 5-day study period was significantly higher in the droperidol group (198) than in the granisetron (73) or combination group (78).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::47323a1a0ada1e2326e4c5f4c35a0d83 https://pubmed.ncbi.nlm.nih.gov/10781162 Zobrazit plný text záznamu Plný text