| Autor: |
L G, MacDougall, A, Taylor-Smith, A D, Rothberg, P D, Thomson |
| Rok vydání: |
1984 |
| Předmět: |
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| Zdroj: |
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 66(1) |
| ISSN: |
0256-9574 |
| Popis: |
This report describes the severe multisystem toxicity which followed ingestion of 5 piroxicam capsules (100 mg) by a 2-year-old child. Gastro-intestinal symptoms developed within 2 hours, resulting in severe fluid and electrolyte imbalance, mental confusion and a generalized seizure. Evidence of liver and renal dysfunction developed within 3 days. Haemopoietic toxicity was manifested by progressive peripheral pancytopenia, bone marrow aplasia and coagulopathy. Pseudomonas septicaemia developed during the period of neutropenia. Clinical, biochemical and haematological abnormalities slowly resolved over 3-4 weeks. In view of the increasing use of piroxicam as an anti-inflammatory agent it seemed important to draw attention to the potentially serious effects of accidental overdosage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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