| Autor: |
Chun-Jie, Wang, Siriguleng, Yu, Ao-Ri-Ge-le, De-Gang, Jia, Hong-Qiang, Yao, Huai-Ping, Zhao, H S, Lillehoj, Si-Mu-Ji-de, Andrew Cl, Postnikoff, Si-Ri-Gu-Leng, Xu |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Brazilian Journal of Microbiology |
| ISSN: |
1517-8382 |
| Popis: |
Two-day-old specific pathogen-free (SPF) chickens were divided into two groups. Group I was inoculated orally with fowl adenovirus Ⅷ (FAV-Ⅷ). Group II served as a negative control. Chickens were investigated at various days post-inoculation (dpi) by flow cytometric analysis for changes in T lymphocyte subpopulations in immune system and blood. In the thymus, CD3(+)T lymphocytes were increased at 25 dpi, with significant increases in the FAV infected noted at 1, 12, 20dpi (p0.05). This was accompanied by a corresponding increase of CD4(+) and CD8(+) T lymphocytes. In the spleen, CD3(+) and CD4(+) T lymphocytes were increased significantly at 30 dpi (p0.01) whereas CD8(+) and TCR γ δ(+) T lymphocytes were decreased at 1 (p0.05), 30 dpi (p0.01). An increase of CD3(+), CD4(+) and CD8(+) T lymphocytes was noticed in peripheral blood, and accompanied by a decrease of TCR γ δ(+) T lymphocytes. These results demonstrated that infection with FAV-Ⅷ causes significant fluctuations in T lymphocyte subpopulations in thymus, blood and spleen. It can be concluded that an infection with FAV-Ⅷ has profound effects on the immune system, especially on cell mediated immune competency. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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